Abstract Background Protein-DNA interaction governs a large number of cellular processes, and it can be altered by a small fraction of interface residues, i.e., the so-called hot spots, which account for most of the interface binding free energy.Accurate prediction of hot spots is critical to understand the principle of protein-DNA interactions.The
In an effort to discover new mouse models of cardiovascular disease using N-ethyl-N-nitrosourea (ENU) mutagenesis followed by high-throughput phenotyping, we have identified a new mouse mutation, C699Y, Glasschaber in the LDL receptor (Ldlr), named wicked high cholesterol (WHC).When WHC was compared with the widely used Ldlr knockout (KO) mouse, no
Animal gut microbiomes play important roles in the health, diseases, and production of animal hosts.The volume of animal gut metagenomic data, including both 16S amplicon and metagenomic sequencing data, has been increasing exponentially in recent years, making it increasingly difficult for researchers to query, retrieve, and reanalyze experimental
Abstract Background Cis-natural antisense transcripts (cis-NATs) are RNAs transcribed from the antisense strand of a gene locus, and are complementary to the RNA transcribed from the sense strand.Common techniques including microarray approach and analysis of transcriptome databases are the major ways to globally identify cis-NATs in various eukary
Abstract Background Coxsackievirus A9 (CA9) was one of the most prevalent serotype of enteroviral infections in Taiwan in 2011.After several patient series were reported in the 1960s and 1970s, few studies have focused on the clinical manifestations of CA9 infections.Our study explores and deepens the current understanding of CA9.Methods We analyze